Modulation of cellular immunity by antibodies against calreticulin

Differential Modulation of SERCA2 Isoforms by Calreticulin

In Xenopus laevis oocytes, overexpression of calreticulin suppresses inositol 1,4,5-trisphosphate-induced Ca2+ oscillations in a manner consistent with inhibition of Ca2+ uptake into the endoplasmic reticulum. Here we report that the alternatively spliced isoforms of the sarcoendoplasmic reticulum Ca2+-ATPase (SERCA)2 gene display differential Ca2+ wave properties and sensitivity to modulation ...

Modulation of cellular morphology and locomotory activity by antibodies against myosin

Three monoclonal antibodies directed against chicken brush border myosin were used to study the possible function of myosin in microfilament organization and locomotion of chicken fibroblasts. These antibodies bind to distinct and separate epitopes on the heavy chain of chicken nonmuscle myosin and display differential effects of myosin filament formation and actin-myosin interaction (Citi, S.,...

Antibodies testing, Immunity and immunity passport in Covid-19

The global outbreak of coronavirus disease-2019 (COVID-19) has affected most countries in the world. Our knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evolving, and it is important to have a clear understanding of the nature of the tests and the interpretation of their findings. In this paper, the purpose is to interpret the results of two typ...

Using monoclonal antibodies to stimulate antitumor cellular immunity.

Monoclonal antibodies (mAbs) have an established role in current cancer therapy with seven approved for the treatment of a wide variety of tumors. The approved mAbs directly target tumor cells; however, it is becoming increasingly clear that as well as their direct effects, these mAbs can present antigens to the immune system. This stimulates long-lasting T-cell immunity, which may correlate wi...

Ups and downs of mucosal cellular immunity against protozoan parasites.